UAMS News
September 30, 2003
Dr. Robert W. Bradsher of UAMS to Present “HIV/AIDS Update” Oct. 30 in El Dorado
Dr. Robert W. Bradsher of UAMS to Present
“HIV/AIDS Update” Oct. 30 in El Dorado
September 29, 2003
UAMS Expert to Discuss Chronic Ear Infection, Hearing Loss Oct. 21 in Jonesboro
UAMS Expert to Discuss Chronic Ear Infection, Hearing Loss Oct. 21 in Jonesboro
September 23, 2003
Arts of UAMS Features Underwater Photographs, Oil Paintings
Arts of UAMS Features Underwater Photographs, Oil Paintings
September 17, 2003
UAMS Receives $1.5 Million for Bioterrorism Preparation in Arkansas
UAMS Receives $1.5 Million for Bioterrorism Preparation in Arkansas
September 15, 2003
UAMS Co-Sponsors Free Diabetes Video Conference Oct. 7 – 8
UAMS Co-Sponsors Free Diabetes Video Conference Oct. 7 – 8
September 10, 2003
UAMS Laser Scientist “Tags” Gold Particle Targets to Kill Breast Cancer Cells
UAMS Laser Scientist “Tags” Gold Particle Targets to Kill Breast Cancer Cells
September 4, 2003
UAMS Surgeon Elected to American Orthopaedic Association
UAMS Surgeon Elected to American Orthopaedic Association, LITTLE ROCK – Richard W. Nicholas, M.D., a professor in the Departments of Orthopaedic Surgery and Pathology in the College of Medicine and director of clinical services for the Arkansas Cancer Research Center (ACRC) at the University of Arkansas for Medical Sciences (UAMS), has been inducted into the exclusive American Orthopaedic Association.
Nicholas’ specialties are musculoskeletal oncology and limb salvage.
To be selected for membership in the association, a candidate must demonstrate leadership in the orthopaedic community, make significant contributions to the field of orthopaedics, and be certified by the American Board of Orthopaedic Surgery or be a Fellow of the Royal College of Surgeons of Canada in Orthopaedic Surgery.
UAMS Cancer Researcher Obtains $1.5 Million for Study of Bone Cancer
UAMS Cancer Researcher Obtains $1.5 Million for Study of Bone Cancer, LITTLE ROCK – Ralph D. Sanderson, Ph.D., of the Arkansas Cancer Research Center (ACRC), part of the University of Arkansas for Medical Sciences (UAMS), has obtained a $1.5 million grant from the National Cancer Institute for his groundbreaking work on the growth of tumor cells in bone.
Sanderson will lead a team of researchers studying heparan sulfate proteoglycans, molecules made by tumor cells which can regulate the ability of the tumors to grow and metastasize. The ACRC team is investigating the processes by which heparan sulfate chains are released by an enzyme called heparanase. They believe this enzyme causes heparan sulfate to activate tumor cells and stimulatetumor metastasis to bone.
Sanderson is internationally known for his research. Since he joined the UAMS faculty in 1989, he has received continuous funding for his research from the National Institutes of Health and the Arthritis Foundation. He is the Drs. Mae and Anderson Nettleship Endowed Chair in Oncologic Pathology in the UAMS College of Medicine.
Thomas J. Kelly, Jr., Ph.D., an expert in degradative enzymes, and Larry J. Suva, Ph.D., an expert in bone biology, will collaborate with Sanderson. Kelly and Suva are also members of ACRC.
During their five-year study, the researchers will focus on breast cancer and myeloma specifically, but their findings may be applicable to other cancers that invade and destroy the skeleton. The researchers believe their work will provide insight into the mechanistic process of tumor bone destruction, and may identify new therapeutic targets.
Heparan sulfate is a carbohydrate (sugar) chain that is biologically active, binding to various “effector” molecules involved in cell signaling. Heparanase is an enzyme that will break down heparan sulfate chains into much shorter chains. That produces many more molecular chains that are still biologically active. These chains can stimulate the tumor to grow and metastasize.
By preventing the breakdown of heparan sulfate, tumor growth may be inhibited. This study could help determine if any of the several heparanase inhibitors now being used in clinical trials are effective in the prevention of bone metastasis.
September 3, 2003
Breast Cancer License Plate Inspired by a Survivor
<span class=”content” style=”font-size: 11.5pt; color: black; font-family: megagl+timesnewroman;”>The long-awaited Arkansas “Cure Breast Cancer” car license plates are now available – and proceeds go to cancer research at the University of Arkansas for Medical Sciences (UAMS) and to the Susan G. Komen Breast Cancer Foundation.</span>
September 2, 2003
Tiny Hands Monster Bash Oct. 25 to Benefit UAMS Family Home
<span style=”font-size: 11.5pt; color: black; line-height: 200%; font-family: gjgpcn+timesnewroman;”>The first annual Tiny Hands Monster Bash will be Sat., Oct. 25, at Next Level Events in Union Station, 1400 W. Markham in downtown Little Rock, Tickets are $30 for the public and $25 for UAMS employees.</span>
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